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KMID : 1141020210210010001
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Journal of Applied Oriental Medicine
2021 Volume.21 No. 1 p.1 ~ p.10
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The Effects of Fermented Soybean Food with Herbal Medicine On Liver and Kidney Function Markers in Type 1 Diabetic Rat models.
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Jo Chang-Suk
Kim So-Young
Choi Moon-Yeol
Kim Mi-Hyeong
Kim Mi-Ryeo
Seo Bu-Il
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Abstract
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Objective : Diabetes mellitus (DM) is a chronic metabolic disorder characterized by high blood glucose levels due to the relative or absolute deficiency of insulin action, and has become a major public health and economic problem worldwide. Godjang (GJ) was made by fermentation of soybean with herbal medicine. The purpose of this study was to investigate the effects of Godjang (GJ) water extracts on antidiabetic markers in streptozotocin (STZ, 65 mg/kg of BW, IP injection)-induced type 1 diabetic rats.
Methods : Experimental DM was induced by intraperitoneal injection with a single dose of STZ (65 ㎎/㎏) in Sprague Dawley rats. In other words, animals were divided into 4 groups; NG (normal group + 0.9% saline), COS (diabetic group + 0.9% saline), GJ 200 (diabetic group + Godjang (200 mg/ kg, BW)), GJ 600 (diabetic group + Godjang (600 ㎎/㎏, BW)). Treatments were performed orally administration for 4 weeks. After the experiment of 4 weeks, the blood samples and organs were collected and then serum levels of glucose, BUN, creatinine, TC, TG, ATS and ALT were measured, respectively.
Results : At the 4 weeks of GJ administration, the body weight gain were lower in diabetic groups than normal group. The serum glucose levels were significantly lower in the GJ 200 and 600 group than COS group. In serum, AST and TG levels significantly decreased in GJ 600 group compared to COS group. The serum levels of ALT, TC, BUN and creatinine were decreased in GJ 200 and 600 groups compared to COS group.
Conclusion : Our results suggest that Godjang water extracts would have antidiabetic effects in STZ-induced diabetic rats.
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KEYWORD
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Godjang water extract, Anti-diabetic, Streptozotocin-induced
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